https://sjms.sfulib10.publicknowledgeproject.org/scandjms <p>Scandinavian Journal of Materials Science (ScandJMS) is a new Open Access journal covering all fields of material science; metals, ceramics, glasses, polymers and composites. Learn more about the journal's <a href="https://scandjms.com/index.php/scandjms/about">Aims &amp; Scope</a>.</p> Medical Journals Sweden AB en-US Scandinavian Journal of Materials Science 2004-2124 <p>This is an Open Access article distributed under the terms of the <span style="font-family: 'Noto Sans', 'Noto Kufi Arabic', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen-Sans, Ubuntu, Cantarell, 'Helvetica Neue', sans-serif;">Creative Commons Attribution-NonCommercial 4.0 International License</span> (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.</p> https://sjms.sfulib10.publicknowledgeproject.org/scandjms/article/view/41 <p><strong>Objective:</strong> The continuing rise of prescription drug abuse has greatly necessitated the development of an abuse-deterrent formulation. Geopolymers are a promising base for drug design as they allow for tuneable drug release and possess superior physical and chemical properties compared with conventional pharmaceutical excipients.<br /><strong>Methods:</strong> Geopolymer pellets containing zolpidem tartrate were administrated orally to beagle dogs as a controlled-release formulation with the commercial immediate-release product, Stilnoct^® tablets, as the control.<br /><strong>Results:</strong> The administration of zolpidem tartrate as immediate-release tablets demonstrated an elevated immediate release plasma profile and the zolpidem tartrate in the geopolymers demonstrated a controlled-release plasma profile. The pharmacokinetic analysis demonstrated that immediate-release tablet administration generated much higher plasma concentration when compared with geopolymer pellets administration for zolpidem tartrate. On the other hand, the geopolymer formulation prolonged the time of drug release.<br /><strong>Conclusion:</strong> Oral administration of zolpidem tartrate in geopolymer pellets demonstrated a controlled-release plasma profile.</p> Amina Vazda Wei Xia Håkan Engqvist Copyright (c) 2021 Amina Vazda, Wei Xia, Håkan Engqvist https://creativecommons.org/licenses/by-nc/4.0 2021-10-19 2021-10-19 1 6 10.2340/scandjms.v1.41 https://sjms.sfulib10.publicknowledgeproject.org/scandjms/article/view/883 Håkan Engqvist Håvard Haugen Copyright (c) 2021 Håkan Engqvist, Håvard Haugen https://creativecommons.org/licenses/by-nc/4.0 2021-11-23 2021-11-23 10.2340/scandjms.v1.883