https://sjms.sfulib10.publicknowledgeproject.org/scandjms/issue/feed 2021-11-22T02:06:49-08:00 Ingrid Honeth ingrid.medicaljournals@gmail.com Open Journal Systems <p>Scandinavian Journal of Materials Science (ScandJMS) is a new Open Access journal covering all fields of material science; metals, ceramics, glasses, polymers and composites. Learn more about the journal's <a href="https://scandjms.com/index.php/scandjms/about">Aims &amp; Scope</a>.</p> https://sjms.sfulib10.publicknowledgeproject.org/scandjms/article/view/41 2021-11-18T02:17:20-08:00 Amina Vazda amina.vazda@angstrom.uu.se Wei Xia wei.xia@angstrom.uu.se Håkan Engqvist hakan.engqvist@angstrom.uu.se

<p><strong>Objective:</strong> The continuing rise of prescription drug abuse has greatly necessitated the development of an abuse-deterrent formulation. Geopolymers are a promising base for drug design as they allow for tuneable drug release and possess superior physical and chemical properties compared with conventional pharmaceutical excipients.<br /><strong>Methods:</strong> Geopolymer pellets containing zolpidem tartrate were administrated orally to beagle dogs as a controlled-release formulation with the commercial immediate-release product, Stilnoct^® tablets, as the control.<br /><strong>Results:</strong> The administration of zolpidem tartrate as immediate-release tablets demonstrated an elevated immediate release plasma profile and the zolpidem tartrate in the geopolymers demonstrated a controlled-release plasma profile. The pharmacokinetic analysis demonstrated that immediate-release tablet administration generated much higher plasma concentration when compared with geopolymer pellets administration for zolpidem tartrate. On the other hand, the geopolymer formulation prolonged the time of drug release.<br /><strong>Conclusion:</strong> Oral administration of zolpidem tartrate in geopolymer pellets demonstrated a controlled-release plasma profile.</p>

2021-10-19T00:00:00-07:00 Copyright (c) 2021 Amina Vazda, Wei Xia, Håkan Engqvist https://sjms.sfulib10.publicknowledgeproject.org/scandjms/article/view/883 2021-11-22T02:06:49-08:00 Håkan Engqvist hakan.engqvist@angstrom.uu.se Håvard Haugen h.j.haugen@odont.uio.no 2021-11-23T00:00:00-08:00 Copyright (c) 2021 Håkan Engqvist, Håvard Haugen